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Updated: Aug 19, 2026

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Published on: February 6, 2018
Paracentric inversion of chromosome 7(q22-31) associated with nonobstructive azoospermia
Kentaro Ichioka1, Koji Yoshimura, Tetsuro Honda
1Department of Urology, Kurashiki Central Hospital, Okayama, Japan. ki7528@kchnet.or.jp
Objective:
To examine an unusual paracentric inversion of chromosome 7 found in an azoospermic man.
Design:
Case report.
Setting:
Infertility clinic at a private hospital.
Patient(S):
An azoospermic but otherwise apparently healthy man.
Intervention(S):
Karyotyping with peripheral blood lymphocytes, microdissection testicular sperm extraction (TESE), and intracytoplasmic sperm injection (ICSI).
Main Outcome Measure(S):
Sperm count and GBG banding.
Results:
A karyogram revealed paracentric inversion of chromosome 7 with breakpoints at 7q22 and 7q31. Testicular histopathology confirmed the Sertoli cell-only syndrome. Successful pregnancy and delivery were achieved with microdissection TESE and ICSI.
Conclusion(S):
Paracentric inversion of chromosome 7(q22-31) associated with nonobstructive azoospermia is rare. Chromosome 7q22-31 may be responsible for impaired spermatogenesis.
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