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Updated: Aug 19, 2026
Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
Published on: February 12, 2018
Autologous heterotopic transplantation of ovarian tissue in sheep
Dominik Denschlag1, Christine Knobloch, Andrea Kockrow
1Department of Obstetrics and Gynecology, University of Freiburg, School of Medicine, Freiburg, Germany. ddenschl@frk.ukl.uni-freiburg.de
Abstract:
The aims of this study were [1] to test the feasibility of autologous heterotopic transplantation of large ovarian tissue samples (approximately 2 cm in diameter and 2 or 3 mm thick) without vascular anastomosis and [2] to compare follicle count and microvessel density in fresh and grafted 2-mm vs. 3-mm tissue samples in an animal model. After transplantation, we observed regular menstrual cycles and ovulation proved by high E(2) levels and intermittent P peaks in all Suffolk sheep, and histologic examination revealed no statistically significant differences in the number of primordial follicles and microvessel density between samples 2 mm and 3 mm in diameter.
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