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Intensive exercise training suppresses testosterone during bed rest.

C E Wade1, K I Stanford, T P Stein

  • 1Life Sciences Division, National Aeronautics and Space Administration Ames Research Center, Moffett Field, California, USA. charles.wade@amedd.army.mil

Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 12, 2005
PubMed
Summary
This summary is machine-generated.

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Prolonged bed rest (BR) and intensive exercise countermeasures did not alter steroidogenesis. However, both isotonic (ITE) and isokinetic exercise (IKE) significantly reduced free and total testosterone levels during BR.

Area of Science:

  • Human Physiology
  • Space Medicine
  • Endocrinology

Background:

  • Spaceflight and prolonged bed rest induce physiological changes, including inconsistent alterations in plasma hormone levels.
  • Exercise is prescribed as a countermeasure to mitigate disuse effects, but its impact on hormone levels requires further investigation.

Purpose of the Study:

  • To evaluate the effect of bed rest (BR) and prescribed exercise countermeasures on plasma steroid levels.
  • To assess the efficacy of isotonic (ITE) and isokinetic exercise (IKE) as countermeasures during 30-day BR.

Main Methods:

  • A 30-day bed rest study involving male subjects.
  • Three groups: no exercise (n=5), isotonic exercise (ITE, n=7), and isokinetic exercise (IKE, n=7).
  • Plasma steroid levels (cortisol, progesterone, aldosterone, free testosterone, total testosterone) were measured.
Keywords:
NASA Center ARCNASA Discipline MusculoskeletalNon-NASA Center

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Main Results:

  • Bed rest alone did not alter steroidogenesis.
  • Both ITE and IKE groups showed significant decreases in free testosterone (FT) and total testosterone (TT) (P < 0.05).
  • FT decreased during IKE and ITE; TT decreased during IKE and ITE, with no association to overtraining.

Conclusions:

  • Intensive exercise countermeasures during BR may contribute to altered plasma steroid concentrations, specifically reducing testosterone levels.
  • The findings support the hypothesis that exercise, while beneficial for strength and aerobic performance, impacts hormonal balance during simulated spaceflight conditions.