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Related Experiment Videos

Urolithiasis associated with topiramate.

Scott Eggener1, Samuel C Kim, Herbert M User

  • 1Department of Urology, Northwestern University Medical School, Chicago, Illinois 60611, USA.

International Braz J Urol : Official Journal of the Brazilian Society of Urology
|February 15, 2005
PubMed
Summary

Topiramate, an anticonvulsant, can cause kidney stones (urolithiasis). A case report highlights this risk, emphasizing the need for awareness among healthcare providers managing urinary stone disease.

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Area of Science:

  • Nephrology
  • Pharmacology

Background:

  • Topiramate is an anticonvulsant medication used for epilepsy and migraine prevention.
  • It is a sulfamate-substituted monosaccharide with a known association with metabolic acidosis and kidney stone formation.

Observation:

  • A 35-year-old male patient on topiramate (375 mg/day) presented with severe flank pain.
  • Imaging revealed a ureteral stone causing hydroureteronephrosis.
  • The extracted stone was primarily composed of carbonate apatite with calcium oxalate.

Findings:

  • This case demonstrates topiramate-induced urolithiasis.
  • The stone composition suggests a complex metabolic disturbance potentially linked to topiramate use.

Implications:

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  • Clinicians should consider topiramate as a potential cause of urolithiasis in patients presenting with kidney stones.
  • Increased vigilance and patient counseling regarding this adverse effect are warranted.