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Published on: February 9, 2019
Ubidecarenone nanoemulsified composite systems
F Carli1, E E Chiellini, B Bellich
1Remedia Srl, Via J. Ressel, 2/7-34108 Dolina (Trieste), Italy.
Abstract:
The nanoemulsified composite (NEC) delivery system is a patented technology based on the incorporation of a double microemulsion into microporous carrier. This approach was applied on the very water insoluble ubidecarenone drug. The resulting composite powder showed good technological properties such as flowability; also good stability was evidentiated, with size of the nano-droplets released from the systems maintained equal to the starting size also after a long storage. Furthermore very good biopharmaceutical properties were originated, with water solubility concentrations up to 50-fold higher than pure ubidecarenone and oral absorption in rats up to three-fold greater than standard commercial products in terms of plasma levels and AUC.
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