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Silica coatings on clarithromycin.

Marjan Bele1, Dorde Dmitrasinovic, Odon Planinsek

  • 1National Institute of Chemistry Slovenia, Hajdrihova 19, 1000 Ljubljana, Slovenia. marjan.bele@ki.si

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Silica coatings on clarithromycin particles were developed using tetraethyl orthosilicate. Cetylpyridinium chloride in the silica coating slightly reduced clarithromycin dissolution rates.

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Area of Science:

  • Pharmaceutical Science
  • Materials Science
  • Chemical Engineering

Background:

  • Clarithromycin is a widely used antibiotic.
  • Controlling drug dissolution rates is crucial for effective drug delivery.
  • Silica coating is a potential method for modifying drug properties.

Purpose of the Study:

  • To develop silica-coated clarithromycin particles.
  • To investigate the effect of silica coating on clarithromycin dissolution.
  • To explore the influence of process parameters and surfactants on coating properties.

Main Methods:

  • Pre-crystallized clarithromycin particles were coated with silica using a tetraethyl orthosilicate (TEOS)-based system.
  • The silica coating process involved ethanol and aqueous ammonia.
  • The effect of cetylpyridinium chloride, a cationic surfactant, on coating properties and dissolution was examined.

Main Results:

  • Silica coatings of 100-150 nm thickness were achieved, comprising approximately 15 wt.% of the composite.
  • Coating properties were influenced by reactant concentration, temperature, and mixing rate.
  • The presence of cetylpyridinium chloride resulted in a slight decrease in the dissolution rate of clarithromycin.

Conclusions:

  • Silica coating can be successfully applied to clarithromycin particles.
  • The dissolution rate of clarithromycin can be modulated by silica coating, particularly in the presence of cetylpyridinium chloride.
  • This approach offers potential for controlled release formulations of clarithromycin.