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Updated: Aug 19, 2026

Recapitulation of an Ion Channel IV Curve Using Frequency Components
Published on: February 8, 2011
Investigating interaction of ligands with voltage dependent anion channel through noise analyses
Jyotirmoy Banerjee1, Subhendu Ghosh
1Department of Biophysics, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India.
Abstract:
Ion channel-protein complexes inserted in the membrane act as molecular gates for transport across the membrane. The opening and closing of these gates can be controlled by one or more variables like ligands (small molecules, proteins, etc.), transmembrane voltage, and the concentration gradient of a chemical across the membrane. We have shown how current noise profile of voltage dependent anion channel can be used to monitor change in the gating of the channel after its modulation by various ligands. This is being proposed as a novel method to probe the interaction of ion channels with ligands.
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