Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multidisciplinary protocol for determining aminoglycoside dosage.

T J Lynch1, C J Possidente, W G Cioffi

  • 1Department of Pharmacy, Medical Center Hospital of Vermont, Burlington 05401.

American Journal of Hospital Pharmacy
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2018
Same author

Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Butyrylcholinesterase: an enzyme antidote for cocaine intoxication.

Addiction biology·2016
Same author

Clinical outcomes in elderly patients with advanced non-small cell lung cancer: results from ARIES, a bevacizumab observational cohort study.

Clinical oncology (Royal College of Radiologists (Great Britain))·2015
Same author

Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2012
Same journal

National health care reform, Part 2: Response to pharmacists.

American journal of hospital pharmacy·1994
Same journal

Validity of originality assessment.

American journal of hospital pharmacy·1994
Same journal

Unit dose dispensing of chromic phosphate P 32 suspension.

American journal of hospital pharmacy·1994
Same journal

Hydralazine injection still available.

American journal of hospital pharmacy·1994
Same journal

Improved extemporaneous formulation of cyclosporine ophthalmic drops.

American journal of hospital pharmacy·1994
Same journal

Paclitaxel diluent and the case of the slippery spike.

American journal of hospital pharmacy·1994
See all related articles

This study introduces an aminoglycoside dosing protocol for surgical patients, improving therapeutic drug levels within 48 hours. The collaborative approach enhanced safety and efficiency in managing aminoglycoside therapy.

Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Infectious Disease Management

Background:

  • Aminoglycoside antibiotics require careful dosing to balance efficacy and toxicity.
  • Optimizing early-stage aminoglycoside therapy is crucial for surgical patients.
  • Existing dosing methods may lack consistency and efficiency.

Purpose of the Study:

  • To describe and evaluate a collaborative protocol for optimizing aminoglycoside dosing in surgical patients.
  • To assess the protocol's impact on achieving therapeutic and nontoxic drug concentrations.
  • To determine the protocol's effect on drug monitoring efficiency and patient safety.

Main Methods:

  • Development of a multidisciplinary aminoglycoside dosing protocol involving physicians, nurses, and pharmacists.

Related Experiment Videos

  • Utilization of a nomogram for initial dose calculation and an antimicrobial order form.
  • Implementation of standardized procedures for drug administration, blood sampling, and serum concentration monitoring.
  • Retrospective review of surgical patient records before and after protocol implementation.

    • Main Results:

    • A higher percentage of patients achieved therapeutic, nontoxic aminoglycoside dosages within 48 hours under the protocol.
    • Reduced number of serum drug concentration tests per patient, with a higher percentage of useful results.
    • No significant change in the mean duration of aminoglycoside therapy.
    • A trend towards fewer nephrotoxic reactions in patients managed with the protocol.

    Conclusions:

    • The collaborative aminoglycoside dosing protocol ensures consistent, safe, and effective management of aminoglycoside therapy.
    • Multidisciplinary cooperation is key to optimizing antibiotic dosing and patient outcomes.
    • The protocol improves therapeutic drug monitoring efficiency and potentially reduces adverse events.