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Disease-specific target selection: a critical first step down the right road
Allen D Roses1, Daniel K Burns, Stephanie Chissoe
1GlaxoSmithKline R&D, Research Triangle Park, NC 27709, USA. allen.d.roses@gsk.com
Drug Discovery Today
|February 15, 2005
Summary
This study introduces a novel program for identifying human disease-specific drug targets early. It uses high-throughput genetic associations to find potential targets for diseases like type 2 diabetes mellitus.
Area of Science:
- Genetics
- Pharmacology
- Biotechnology
Background:
- Drug target relevance is often based on weak evidence.
- Identifying reliable disease-specific drug targets is crucial for therapeutic development.
Purpose of the Study:
- To describe a program for early identification of human disease-specific drug targets.
- To present methods and data analyses for target gene identification in type 2 diabetes mellitus.
Main Methods:
- Screening large patient cohorts (>1000) and controls for genetic associations.
- Utilizing over 7000 single nucleotide polymorphisms from >1500 genes.
- Employing statistical permutation methodology for data analysis and variable correction.
Main Results:
- Identification of potential drug target genes for type 2 diabetes mellitus.
- Demonstration of a high-throughput genetic association screening approach.
Conclusions:
- The described program enables early identification of disease-specific drug targets.
- High-throughput genetic association screening is a viable method for drug discovery.