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Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
Published on: October 6, 2023
Radiographic progression in children with polyarticular juvenile rheumatoid arthritis: a pilot study
T Mason1, A M Reed, A M Nelson
1Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA. mason.thomas@mayo.edu
Annals of the Rheumatic Diseases
|February 15, 2005
Summary
About half of children with polyarticular juvenile rheumatoid arthritis show radiographic progression within two years. This indicates a high risk of joint destruction and disability, underscoring the need for early intervention in pediatric rheumatoid arthritis.
Area of Science:
- Pediatric Rheumatology
- Radiology
- Rheumatoid Arthritis
Background:
- Polyarticular juvenile rheumatoid arthritis (pJRA) is a chronic autoimmune disease affecting multiple joints in children.
- Early detection of disease progression is crucial for managing joint destruction and potential disability.
Purpose of the Study:
- To evaluate radiographic disease progression in the hands and wrists of children diagnosed with polyarticular juvenile rheumatoid arthritis.
Main Methods:
- Hand/wrist X-rays from 13 children with pJRA were reviewed blindly by a pediatric radiologist.
- Evaluated parameters included joint space narrowing (JSN), erosions, and relative carpal length (RCL).
- Initial and subsequent X-rays were compared to assess changes over time.
Main Results:
- Four initial X-rays showed evidence of erosions or JSN.
- Subsequent X-rays, taken at a median of 13.3 months, revealed radiographic progression in six of 13 children.
- Progression included new erosions, increased erosions, and new JSN.
Conclusions:
- Approximately 50% of children with pJRA experience radiographic progression within two years post-diagnosis.
- Newly diagnosed children with pJRA are at significant risk for substantial joint destruction and functional disability.
- Prompt and effective treatment is essential to mitigate long-term joint damage and disability in pediatric rheumatoid arthritis.
