Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Psoriasis pathophysiology: current concepts of pathogenesis.

J G Krueger1, A Bowcock

  • 1Laboratory for Investigative Dermatology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA. jgk@rockefeller.edu

Annals of the Rheumatic Diseases
|February 15, 2005
PubMed
Summary

Psoriasis vulgaris is an autoimmune skin disease involving T lymphocytes. Current research focuses on genetic and cellular pathways, leading to new targeted therapies for this common condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bimekizumab for the treatment of moderate-to-severe plaque psoriasis: efficacy, safety, pharmacokinetics, pharmacodynamics and transcriptomics from a phase IIa, randomized, double-blind multicentre study.

The British journal of dermatology·2021
Same author

Response to 'Lack of efficacy of dupilumab in the treatment of keloid disorder' by MH Tirgan and J Uitto.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Assessing the responsiveness of sonographic biomarkers to Brodalumab therapy in Hidradenitis Suppurativa.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Large-scale serum analysis identifies unique systemic biomarkers in psoriasis and hidradenitis suppurativa.

The British journal of dermatology·2021
Same author

The Impact of Body Mass Index Upon the Efficacy of Adalimumab in Hidradenitis Suppurativa.

Frontiers in medicine·2021
Same author

Signalling of multiple interleukin (IL)-17 family cytokines via IL-17 receptor A drives psoriasis-related inflammatory pathways.

The British journal of dermatology·2021

Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Psoriasis vulgaris is a common skin disorder with inflamed, scaly plaques.
  • Key features include epidermal hyperplasia, vascular changes, and immune cell infiltration.
  • It is increasingly understood as a T lymphocyte-mediated autoimmune disease.

Purpose of the Study:

  • To review current pathogenic concepts of psoriasis vulgaris.
  • To highlight insights from genetic, genomic, and cellular studies.
  • To discuss advancements in targeted immune therapies.

Main Methods:

  • Review of genetic and genomic data.
  • Analysis of cellular and molecular pathways.
  • Evaluation of clinical studies on immune-targeting drugs.

Related Experiment Videos

Main Results:

  • Identification of key cellular changes in psoriatic skin.
  • Understanding of T lymphocyte's role in pathogenesis.
  • Emergence of biological therapies targeting T cells.

Conclusions:

  • Psoriasis pathogenesis is complex, involving multiple cellular and molecular pathways.
  • Genetic and cellular information is crucial for understanding the disease.
  • Targeted immune therapies represent a significant advancement in managing psoriasis vulgaris.