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Updated: Aug 19, 2026

Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils
Published on: November 16, 2015
The "small, dark tonsil" in patients presenting with metastatic cervical lymphadenopathy from an unknown primary
Jacque R Jumper1, Nancy J Fischbein, Michael J Kaplan
1Department of Neuroradiology, University of California-San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA.
Abstract:
When squamous cell carcinoma (SCC) involves the palatine tonsils, they are generally enlarged and demonstrate intermediate to high signal intensity on T2-weighted MR images and enhance after gadolinium administration. We have identified two patients with SCC of the tonsil where the affected tonsil has low signal intensity on T2-weighted MR images and is smaller than the contralateral normal tonsil. We present the "small, dark tonsil" as an alternative imaging presentation of SCC and a new sign to look for when evaluating the patient with metastatic lymphadenopathy from an unknown primary tumor.
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