Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[A case report of Russel's diencephalic cachexia].

M Gallet1, L Leke, O Kremp

  • 1Service de Pédiatrie II, Centre Hospitalier Universitaire d'Amiens, Hôpital Nord.

Annales De Pediatrie
|March 1, 1992
PubMed
Summary

Diencephalic syndrome of infancy causes severe emaciation. Tumor necrosis factor alpha (TNF alpha) may drive this cachexia, suggesting anti-TNF therapies as a potential treatment for this rare condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Interest of radiotherapy of rectal cancer with synchronous metastases].

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2008
Same author

Splenic marginal zone lymphomas and lymphoplasmacytic lymphomas originate from B-cell compartments with two different antigen-exposure histories.

Leukemia·2008
Same author

[Children arthropod bites protective measures: insecticides and repellents].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2007
Same author

[Intersphincteric rectal resection].

Journal de chirurgie·2007
Same author

[Pneumococcal infection among community-acquired pneumonia. A retrospective study of 230 hospitalized children].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2007
Same author

Laparoscopic approach in surgical treatment of rectal cancer.

The British journal of surgery·2007

Area of Science:

  • Pediatric Neurology
  • Oncology
  • Endocrinology

Background:

  • Diencephalic syndrome of infancy is a rare condition characterized by severe emaciation and failure to thrive.
  • Ocular anomalies, such as strabismus and nystagmus, can be presenting symptoms.
  • Diagnostic imaging modalities like MRI and ultrasonography are crucial for identifying the syndrome.

Observation:

  • A case report details an infant with severe emaciation and intermittent ocular issues.
  • The infant's cachexia was disproportionate to tumor spread, prompting investigation into underlying pathophysiology.
  • Magnetic resonance imaging and transfontanellar ultrasonography confirmed the diagnosis.

Findings:

  • Pathophysiological hypotheses for cachexia in diencephalic syndrome are reviewed.

Related Experiment Videos

  • Tumor necrosis factor alpha (TNF alpha), a potent lipolytic agent, is implicated in other cachexia conditions but not previously studied in this syndrome.
  • Excessive TNF alpha production is hypothesized to contribute to the characteristic emaciation.

    • Implications:

    • This study suggests a potential role for TNF alpha in the cachexia associated with diencephalic syndrome of infancy.
    • Targeting TNF alpha with monoclonal antibodies could represent a novel therapeutic strategy for managing emaciation in affected infants.
    • Further research is warranted to validate the role of TNF alpha and the efficacy of anti-TNF therapies.