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Clusterin and Alzheimer's disease
Miguel Calero1, Agueda Rostagno, Blas Frangione
1Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain.
Sub-Cellular Biochemistry
|February 16, 2005
Summary
Clusterin, a multifunctional protein, interacts with Alzheimer's Abeta peptides and is implicated in amyloid disorders. Its varied roles in health and disease depend on maturation and localization.
Area of Science:
- Biochemistry
- Neuroscience
- Molecular Biology
Background:
- Clusterin (apolipoprotein J) is a ubiquitous glycoprotein known for interacting with various molecules, including the Alzheimer's amyloid-beta (Abeta) peptide.
- Its presence in fibrillar deposits in systemic and cerebral amyloid disorders classifies it as an amyloid-associated protein.
Purpose of the Study:
- To review the significance of clusterin in both health and disease.
- To emphasize clusterin's specific role in Abeta amyloidosis and other protein misfolding disorders.
Main Methods:
- Literature review focusing on clusterin's functions.
- Analysis of clusterin's involvement in amyloidogenesis and protein folding diseases.
Main Results:
- Clusterin interacts with the Alzheimer's Abeta peptide and is found with amyloid deposits.
- The protein's function is context-dependent, influenced by maturation, localization, and cellular factors.
Conclusions:
- Clusterin plays a multifaceted role in physiological and pathological processes, particularly in Abeta amyloidosis.
- Understanding clusterin's varied functions is crucial for comprehending protein folding disorders.