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Updated: Jul 26, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
Published on: July 21, 2013
An unusual cause of abrupt vessel closure
J B Foley1, J Cosgrave, D S O'Briain
1St James Hospital, James Street, Dublin 8, Republic of Ireland. bfoley@stjames.ie
Insights
A rare cause of cardiac arrest after a heart procedure was identified: embolization of material from a guiding catheter. This material, along with a thrombus, blocked a stent, leading to fatal coronary artery occlusion.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Pathology
Background:
- Percutaneous coronary intervention (PCI) is a common procedure for treating coronary artery disease.
- Coronary artery occlusion can lead to myocardial infarction and cardiac arrest.
- Embolic events are a known complication of cardiovascular procedures.
Observation:
- A 60-year-old woman experienced chest pain, ECG changes, and a circumflex artery lesion.
- Following successful PCI, the patient suffered a cardiac arrest and died.
- Postmortem examination revealed a blocked stent containing thrombus and unusual translucent material.
Findings:
- The translucent material was identified as originating from the lining of the guiding catheter used during PCI.
- This catheter-derived material, combined with thrombus, caused complete occlusion of the stented circumflex artery.
- This represents the first reported case of coronary artery embolization caused by guiding catheter lining material.
Implications:
- Highlights a novel embolic mechanism in interventional cardiology.
- Suggests the need for vigilance regarding potential complications from medical device materials.
- Underscores the importance of thorough postmortem examination in unexplained procedural deaths.
Abstract:
A 60 year old woman presented with chest pain. An ECG showed ST depression across the anterior leads and lateral T wave inversion and angiography showed a significant proximal circumflex lesion. After percutaneous intervention to the circumflex artery she had a cardiac arrest and died. Postmortem examination found a stent blocked with a combination of thrombus and a tangle of translucent material. Embolic coronary artery occlusion is well described but this is the first report of embolisation of material arising from the lining of the guiding catheter as the cause.
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