Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blood gene expression profiling of neurologic diseases: a pilot microarray study.

Yang Tang1, Donald L Gilbert, Tracy A Glauser

  • 1Department of Neurology and Neuroscience Program, University of Cincinnati, OH, USA.

Archives of Neurology
|February 16, 2005
PubMed
Summary

Peripheral blood gene expression patterns can identify neurologic diseases like neurofibromatosis type 1 and epilepsy. This blood gene profiling may serve as a surrogate marker for conditions lacking clear blood phenotypes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cluster Analysis of Migraine-Associated Symptoms (CAMS) across the lifespan: a cross-sectional study.

BMC neurology·2026
Same author

Trio analysis in dystonia identifies de novo KLC1 variants in a kinesinopathy with distinct motor and neurodevelopmental features.

EBioMedicine·2026
Same author

Multiecho Resting-State Functional Magnetic Resonance Imaging Analysis of Attention-Deficit/Hyperactivity Disorder Severity and Motor Dysfunction in a Pediatric Sample of Neurofibromatosis Type 1.

Pediatric neurology·2026
Same author

Treatment outcomes in new daily persistent headache in children and adolescents.

Cephalalgia : an international journal of headache·2026
Same author

Treatment non-persistence in children and adolescents with Tourette syndrome newly treated with dopamine D2 receptor modulators.

Frontiers in psychiatry·2026
Same author

Education Research: The Future of Child Neurology Residency Training: The Perspective of a Child Neurology Society Task Force.

Neurology. Education·2026

Area of Science:

  • Genomics
  • Neurology
  • Molecular Biology

Background:

  • Gene expression profiling analyzes thousands of genes but is not easily applied to clinical neurology.
  • Peripheral blood offers a potential surrogate tissue for studying neurologic diseases.

Purpose of the Study:

  • To identify unique gene expression patterns in whole blood associated with specific neurologic diseases.
  • To explore the utility of peripheral blood gene expression as a surrogate marker for neurologic conditions.

Main Methods:

  • A case-control study was conducted in university-based neurology clinics.
  • Patients with neurofibromatosis type 1, epilepsy, or Tourette syndrome were compared to controls.
  • Over 12,000 gene expression levels were measured in blood using U95A arrays.

Related Experiment Videos

Main Results:

  • Distinct blood gene expression patterns were observed in neurofibromatosis type 1 and childhood epilepsy.
  • Epilepsy subgroups (valproic acid-responsive vs. refractory) showed distinct gene expression subclusters.
  • Tourette syndrome exhibited several gene expression clusters, with some showing overexpression of immune cell-associated genes.

Conclusions:

  • Blood gene expression profiling can reveal distinct molecular signatures for neurologic diseases.
  • Peripheral blood gene expression serves as a valuable surrogate marker for neurologic conditions, even those without apparent blood phenotypes.