Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunonutrition.

Robert F Grimble1

  • 1Institute of Human Nutrition, School of Medicine, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom. rfg1@soton.ac.uk

Current Opinion in Gastroenterology
|February 16, 2005
PubMed
Summary

Immunonutrients administered enterally improve patient outcomes, especially for malnourished individuals under inflammatory stress from surgery, infection, or cancer. Parenteral immunonutrition offers benefits in specific cases but carries higher risks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy.

Marine drugs·2013
Same author

The conditional role of inflammation in pregnancy and cancer.

Clinical nutrition (Edinburgh, Scotland)·2012
Same author

Variants in the genes encoding TNF-α, IL-10, and GSTP1 influence the effect of α-tocopherol on inflammatory cell responses in healthy men.

The American journal of clinical nutrition·2012
Same author

Docosahexaenoic acid inhibits the adhesion of flowing neutrophils to cytokine stimulated human umbilical vein endothelial cells.

The Journal of nutrition·2011
Same author

The true cost of in-patient obesity: impact of obesity on inflammatory stress and morbidity.

The Proceedings of the Nutrition Society·2010
Same author

Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability.

Atherosclerosis·2010

Area of Science:

  • Clinical Nutrition
  • Inflammation and Immunology
  • Gastroenterology

Background:

  • Inflammatory stress from surgery, infection, and cancer significantly impacts patient outcomes.
  • Nutritional support plays a critical role in managing critically ill patients.
  • The efficacy of specific nutrients in modulating inflammatory responses is an area of active research.

Purpose of the Study:

  • To review recent findings on the effectiveness of immunonutrients in patients experiencing inflammatory stress.
  • To compare enteral and parenteral nutrition strategies in managing inflammatory conditions.
  • To identify key immunonutrients and their specific roles in various clinical scenarios.

Main Methods:

  • Systematic review of recent literature on immunonutrition.

Related Experiment Videos

  • Analysis of clinical trial data comparing different nutritional interventions.
  • Evaluation of the impact of specific immunonutrients (glutamine, omega-3 fatty acids, antioxidants, L-arginine) on patient outcomes.

    • Main Results:

    • Enteral nutrition is generally more effective and safer than parenteral nutrition, reducing infection rates and hospital stays.
    • Immunonutrition benefits are most pronounced in malnourished patients, with perioperative enteral nutrition showing superior efficacy.
    • Specific immunonutrients like glutamine, omega-3 fatty acids, and antioxidants demonstrate positive effects, while L-arginine has complex roles. Intravenous lipids with omega-3 fatty acids and MCTs may be preferable to omega-6 rich lipids.

    Conclusions:

    • Enteral immunonutrition is effective for a broad range of patients, particularly the malnourished, improving clinical outcomes.
    • Parenteral immunonutrition can be beneficial for selected patients unable to receive enteral nutrition, despite higher associated risks.