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Related Experiment Videos

Intrauterine fetal transfusion.

Hisham H Mirghani1, Sarath Weerasinghe, Shamsaa Al-Awar

  • 1Department of Obstetrics & Gynecology, Faculty of Medicine & Health Sciences, United Arab Emirates University, PO Box 17666, Al-Ain, United Arab Emirates. hmirghani@uaeu.a.ae

Saudi Medical Journal
|February 16, 2005
PubMed
Summary

Rh isoimmunization can cause fetal anemia, but successful intrauterine transfusions can lead to healthy outcomes. This case highlights effective management of severe Rh sensitization, preventing stillbirth and ensuring infant survival.

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Area of Science:

  • Obstetrics and Gynecology
  • Immunology
  • Perinatology

Background:

  • Rhesus (Rh) isoimmunization remains a significant cause of fetal anemia, despite advancements in Rh immunoglobulin therapy.
  • Severe Rh sensitization can lead to recurrent stillbirths and fetal hydrops.

Observation:

  • A 38-year-old woman with a history of five stillbirths presented with high titers of anti-D (1/2048) and anti-C (1/256).
  • Ultrasound revealed fetal ascites at 18 weeks gestation, indicating severe hemolytic disease.

Findings:

  • The fetus underwent nine successful intrauterine transfusions, demonstrating the efficacy of this intervention.
  • Delivery via cesarean section at 34 weeks resulted in a healthy female infant weighing 2060 g.

Implications:

Related Experiment Videos

  • This case underscores the critical role of vigilant monitoring and aggressive intrauterine transfusion in managing severe Rh isoimmunization.
  • Successful management can prevent fetal death and ensure normal growth and neurodevelopment in affected infants.