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Updated: Aug 19, 2026

A Microfluidic System for Modeling Endothelial Dysfunction under Combined Physiological Pulsatile Shear Stress and Oscillatory Hyperglycemia
Published on: May 12, 2026
[Diabetic microangiopathy: vascular cell crosstalk in hyperglycaemia]
15. Medizinische Klinik, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim. hans-peter.hammes@med5.ma.uni-heidelberg.de
Abstract:
Diabetic retinopathy is the most common microvascular complication in diabetes mellitus, mostly determined by chronic glycaemia as measured by HbA1c. The sequence of events involves changes in the cellular crosstalk of the retinal capillary, initiated by the loss of intramural pericytes. Data from transgenic and diabetic models allow to assess the relative importance of this phenomenon. New insight into biochemical and cell biological interactions from hyperglycaemia to vascular injury establish metabolic signal blockers as novel therapeutic approaches for diabetic microangiopathy.
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