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Related Experiment Videos

Iphosphamide-induced nephrotoxicity in children.

R Shore1, M Greenberg, D Geary

  • 1Division of Hematology-Oncology, Hospital for Sick Children, Toronto, Canada.

Pediatric Nephrology (Berlin, Germany)
|March 1, 1992
PubMed
Summary
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Ifosfamide-induced nephrotoxicity in children: critical review of predictive risk factors.

Pediatrics·1998

Pediatric nephrotoxicity from ifosfamide is a concern. Younger children and those previously treated with cis-platinum face higher risks, impacting growth.

Area of Science:

  • Pediatric Oncology
  • Nephrology
  • Pharmacology

Background:

  • Ifosfamide is a widely used chemotherapy agent in pediatric oncology.
  • Nephrotoxicity is a known, but not fully understood, adverse effect of ifosfamide treatment.
  • Identifying risk factors for ifosfamide-induced nephrotoxicity is crucial for patient management.

Purpose of the Study:

  • To evaluate the nephrotoxic potential of ifosfamide in children.
  • To identify patient characteristics and co-administered treatments associated with ifosfamide-induced nephrotoxicity.
  • To assess the impact of ifosfamide nephrotoxicity on childhood growth.

Main Methods:

  • Retrospective analysis of children treated with ifosfamide at The Hospital for Sick Children.
  • Comparison of dosage, treatment cycles, and co-exposure to other nephrotoxic agents between children with and without nephrotoxicity.

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  • Statistical analysis to determine significant risk factors and associations.

    • Main Results:

    • Children who developed nephrotoxicity were significantly younger than those with normal renal function.
    • Prior exposure to cis-platinum was a significant risk factor for developing ifosfamide-induced nephrotoxicity.
    • No significant differences in ifosfamide dose or cycles were observed between groups.
    • Nephrotoxicity was associated with a significant negative impact on growth.

    Conclusions:

    • Younger age and prior cis-platinum treatment are key risk factors for ifosfamide-induced nephrotoxicity in children.
    • Close renal function monitoring is essential for all children receiving ifosfamide.
    • Special attention should be given to children under 5 years and those with a history of cis-platinum exposure.