Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Compartmentalized morphogenesis in epithelia: from cell to tissue shape.

Fanny Pilot1, Thomas Lecuit

  • 1Laboratoire de Génétique et de Physiologie du Développement (LGPD), UMR 6545 CNRS-Université de la Méditerranée, Institut de Biologie du Développement de Marseille (IBDM), Marseille, France.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|February 16, 2005
PubMed
Summary

Embryonic tissue shaping involves cell rearrangements like apical constriction and neighbor exchange. These processes, regulated by developmental signals, are crucial for forming body plans and organs across species.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical regulation of cuboidal-to-squamous epithelial transition in the Drosophila developing wing.

Current biology : CB·2026
Same author

Spatial patterning of contractility by a self-organized mechanogen activity gradient underlies Drosophila gastrulation.

Nature communications·2026
Same author

The hard truth about how hard it is to publish in Development.

Development (Cambridge, England)·2026
Same author

Mechanical regulation of substrate adhesion and de-adhesion drives a cell-contractile wave during Drosophila tissue morphogenesis.

Developmental cell·2023
Same author

Serotonin signaling regulates actomyosin contractility during morphogenesis in evolutionarily divergent lineages.

Nature communications·2023
Same author

Growth anisotropy of the extracellular matrix shapes a developing organ.

Nature communications·2023

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Morphogenesis

Background:

  • Embryonic development involves species-specific tissue shaping through conserved morphogenetic processes like tissue folding and elongation.
  • Both mesenchymal and epithelial cells contribute to embryonic tissue remodeling, with epithelial cells maintaining apicobasal organization.
  • Understanding the cellular basis of morphogenesis is key to comprehending body plan organization and organogenesis.

Purpose of the Study:

  • To review and compare compartmentalized cellular rearrangements underlying tissue remodeling in Drosophila with those in other organisms.
  • To elucidate the spatiotemporal control mechanisms governing embryonic tissue shaping.
  • To highlight the roles of localized cell shape changes and developmental signals in morphogenesis.

Main Methods:

Related Experiment Videos

  • Comparative analysis of cellular rearrangements in Drosophila and other model organisms.
  • Review of literature on cell behaviors such as apical constriction, neighbor exchange, and protrusive activity.
  • Examination of how developmental signals regulate cell behaviors and tissue dynamics.

Main Results:

  • Tissue folding and invagination are triggered by contractile activity at the apical cell surface.
  • Polarized neighbor exchange during tissue elongation is controlled by adhesion regulation at adherens junctions.
  • Basolateral protrusive activity contributes to intercalation, another key morphogenetic process.

Conclusions:

  • Localized cellular rearrangements, including apical constriction and junction remodeling, are spatially regulated by developmental signals.
  • These cell shape changes are fundamental to diverse tissue remodeling events across species.
  • The study provides insights into conserved mechanisms of embryonic tissue shaping and organogenesis.