[Influence of compatibility ratio of Fufang Danshen on the dissolution of Danshen compositions]
Related Experiment Video
Updated: Aug 19, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Guifeng Zeng1, Qing Xu, Hongbin Xiao
1Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116011, China.
Abstract:
A high performance liquid chromatographic (HPLC) method has been developed using peak ratio to compare the Danshen ingredients with varying peak ratios of Danshen (Salvia miltiorrhiza Bunge.) to Sanqi (Panax Notoginseng) from 10:0 to 1:10 in Fufang Danshen which is composed of Danshen and Sanqi. The experimental results show that the contents of major components of all samples decocted together are higher than those of Danshen. The contents of Danshen major components are the highest in classic formula (the mass ratio of Danshen to Sanqi is 5:3). Therefore, Danshen decocted together with Sanqi at a ratio of 5:3 can increase the dissolution ability of Danshen ingredients. This, therefore, could constitute a solid rationale to the compatibility rule in Chinese traditional medicine with both scientific merits and intrinsic reasoning.
Related Concept Videos
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Drug Dissolution: Requirements and Profile Comparison
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model
Solubility Equilibria: Overview
Solubility is important in biological and environmental processes. A notable...
Theories of Dissolution: Diffusion Layer Model
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Intermolecular Forces in Solutions
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
