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Updated: Jul 9, 2026

Method to Measure Tone of Axial and Proximal Muscle
Published on: December 14, 2011
Turn and helical peptide handedness governed exclusively by side-chain chiral centers
Soledad Royo1, Wim M De Borggraeve, Cristina Peggion
1Department of Organic Chemistry, ICMA, University of Zaragoza-CSIC, 50009 Zaragoza, Spain.
Abstract:
We have examined the preferred 3D structure of homopeptides based on an alpha-amino acid lacking the asymmetry at the alpha-carbon but exhibiting chirality in the side chains (at the two beta-carbons). These joint stereochemical properties are remarkably unusual for an alpha-amino acid. To this end, we carried out an experimental investigation by X-ray diffraction and NMR spectrometry. The results point to a well-defined relationship between screw sense of the turn and helix structures formed and side-chain configurations.
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