Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteinuria in pre-eclampsia: how much matters?

Patricia Chan1, Mark Brown, Judy M Simpson

  • 1St George Hospital, Kogarah, NSW 2217, Australia.

BJOG : an International Journal of Obstetrics and Gynaecology
|February 17, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High Early Embryo Mortality and Low Hatching Success Observed in Aldabra Giant Tortoise Populations.

Ecology and evolution·2026
Same author

Predicting the Unpredictable: A Data-Driven Machine Learning Model for Emergency Department Waiting Room Surge Status.

Mayo Clinic proceedings. Digital health·2026
Same author

Kidney supportive care in Australia and New Zealand: an ANZSN and ANZSPM guidance document.

Internal medicine journal·2026
Same author

Difelikefalin in gabapentinoid-refractory CKD-associated pruritus: real-world experience from Australia.

Journal of nephrology·2026
Same author

Centre-of-Mass Confounds Contribute to Familiar Size Stroop Effects with Boger and Firestone's 'Visual Anagrams'.

Journal of cognition·2026
Same author

Refractory Chronic Kidney Disease-Associated Pruritus: Old Remedies and Novel Agents.

Kidney medicine·2026

Higher proteinuria levels in pre-eclampsia correlate with increased risks of adverse maternal and fetal outcomes. Specific thresholds, like >900 mg/mmol, indicate a significantly higher likelihood of adverse maternal events.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Nephrology in Pregnancy

Background:

  • Pre-eclampsia is a leading cause of maternal and fetal morbidity.
  • Proteinuria is a key diagnostic marker for pre-eclampsia.
  • Predicting adverse outcomes in pre-eclampsia is crucial for timely intervention.

Purpose of the Study:

  • To investigate the predictive value of proteinuria levels at diagnosis for adverse maternal and fetal outcomes in women with proteinuric pre-eclampsia.
  • To identify potential discriminant values of proteinuria for risk stratification.

Main Methods:

  • Retrospective cohort study of 353 women with proteinuric pre-eclampsia.
  • Logistic regression analysis to identify predictors of adverse outcomes.
  • Calculation of Receiver Operating Characteristic (ROC) curves, sensitivity, and specificity.

Related Experiment Videos

Main Results:

  • Increased spot urine protein/creatinine ratio significantly predicted adverse maternal and fetal outcomes.
  • Higher ratios were associated with increased odds of adverse maternal (OR 1.003 per mg/mmol) and fetal outcomes (OR 1.44 per log [mg/mmol]).
  • Gestation <34 weeks and early systolic BP ≤115 mmHg also predicted adverse fetal outcomes.

Conclusions:

  • Proteinuria levels are valuable in predicting adverse maternal and fetal outcomes in pre-eclampsia.
  • While no single definitive screening value was found, specific ratios (e.g., >900 mg/mmol) indicate greatly increased risk.
  • The findings support using proteinuria data for risk prediction in pre-eclampsia management.