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Effects of local anesthetics on human bladder contractility
Seung-June Oh1, Sung Hyun Paick, Dae Jung Lim
1Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Neurourology and Urodynamics
|February 17, 2005
Summary
Local anesthetics impact human bladder contractility, affecting spontaneous and stimulated contractions. These findings suggest potential therapeutic uses for bladder dysfunction.
Area of Science:
- Urology
- Pharmacology
- Physiology
Background:
- Human bladder contractility is crucial for normal micturition.
- Local anesthetics are commonly used for pain management but their effects on bladder muscle are not fully understood.
Purpose of the Study:
- To investigate the in vitro effects of common local anesthetics on human bladder smooth muscle contractility.
- To determine the differential effects of various local anesthetics on nerve-mediated and direct muscle-induced contractions.
Main Methods:
- Human bladder strips were used to measure isometric contractions in vitro.
- The effects of tetracaine, bupivacaine, lidocaine, and ropivacaine were assessed on basal, spontaneous, and stimulated contractions (KCl, carbachol, EFS).
- The impact on Ca(2+)-independent sustained tonic contraction (SuTC) was also evaluated.
Main Results:
- Local anesthetics increased spontaneous contractions dose-dependently but abolished them at higher concentrations.
- All tested agents inhibited nerve-mediated and non-nerve-mediated contractions in a concentration-dependent manner.
- Higher concentrations were required to inhibit non-nerve-mediated contractions compared to nerve-mediated ones.
Conclusions:
- Local anesthetics exert significant inhibitory effects on human bladder contractility.
- The observed differences in potency suggest potential diagnostic and therapeutic applications for bladder dysfunction.