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Related Experiment Videos

Heart size and function in acromegaly.

H M Mather, M J Boyd, J S Jenkins

    British Heart Journal
    |June 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    In acromegaly patients, increased left ventricular mass was common but heart function remained normal. Controlling growth hormone levels may reduce cardiac hypertrophy, warranting echocardiography for monitoring.

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    Area of Science:

    • Cardiology
    • Endocrinology
    • Internal Medicine

    Background:

    • Acromegaly, a condition caused by excess growth hormone, is known to affect the heart.
    • Cardiac abnormalities in acromegaly can include left ventricular hypertrophy.

    Purpose of the Study:

    • To investigate cardiac size and function in acromegalic patients.
    • To determine the relationship between growth hormone levels and cardiac changes.
    • To assess the potential for regression of cardiac hypertrophy with treatment.

    Main Methods:

    • Echocardiography was used to assess cardiac structure and function.
    • Systolic time interval measurements were performed.
    • Cardiac parameters were correlated with recent basal growth hormone levels.

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    Main Results:

    • 56% of patients exhibited increased left ventricular mass.
    • Increased left ventricular mass correlated with growth hormone levels in treated patients.
    • Left ventricular ejection fraction was normal in most patients, irrespective of mass.

    Conclusions:

    • Acromegalic hearts often maintain normal function despite increased mass.
    • Myocardial hypertrophy may be reversible with controlled growth hormone levels.
    • Echocardiography is a valuable tool for monitoring cardiac effects in acromegaly.