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[Research progress on the oral solid rapidly disintegrating dosage form].

Lan Shen1, Xiao Lin, De-sheng Xu

  • 1Shanghai University of Traditional Chinese Medicine, Shanghai 201203.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|February 18, 2005
PubMed
Summary

Oral solid rapidly-disintegrating dosage forms offer convenient intake, enhanced absorption, and high bioavailability. These innovative formulations show promise for improving traditional Chinese medicine delivery and treating emergencies.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Traditional Chinese Medicine

Background:

  • Oral solid rapidly-disintegrating dosage forms are gaining attention due to their advantages.
  • These include ease of administration, rapid absorption, high bioavailability, and reduced adverse drug reactions.

Purpose of the Study:

  • To introduce the mechanisms behind oral solid rapidly-disintegrating dosage forms.
  • To explore their potential applications in traditional Chinese medicine (TCM).

Main Methods:

  • The article reviews the mechanisms of rapid disintegration and fast dissolution.
  • It also discusses the role of supplementary materials in enhancing drug solubility.

Main Results:

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  • Various dosage forms are discussed, including dispersible tablets, fast dissolving tablets, and solid dispersible technology.
  • These forms can improve the bioavailability of poorly soluble TCM compounds.

    • Conclusions:

    • Oral solid rapidly-disintegrating dosage forms present a novel approach for TCM delivery.
    • They offer potential for emergency treatments and the development of new excipients.