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Evaluation of hepatic transport function by hepatobiliary scintigraphy
H Takikawa1, J Tomita, Y Sekiya
1Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Journal of Gastroenterology and Hepatology
|March 1, 1992
Summary
This study shows that analyzing [99mTc]-pyridoxyl-5-methyltryptophan transport using a three-compartment model is effective for evaluating liver function in patients with chronic liver disease. The hepatic uptake rate constant (k12) is the most sensitive indicator.
Area of Science:
- Nuclear Medicine
- Hepatology
- Pharmacokinetics
Background:
- Chronic viral liver diseases impair hepatobiliary function.
- Accurate assessment of hepatic transport is crucial for patient management.
Purpose of the Study:
- To evaluate the utility of [99mTc]-pyridoxyl-5-methyltryptophan and three-compartment model analysis for assessing hepatic transport function.
- To identify the most sensitive kinetic parameter for differentiating liver diseases.
Main Methods:
- Studied transport kinetics of [99mTc]-pyridoxyl-5-methyltryptophan in 45 patients with chronic viral liver diseases.
- Applied three-compartment model analysis using time-activity curves from heart, liver, and biliary tract/intestine regions.
- Calculated hepatic uptake (k12), efflux (k21), and excretion (ke1) rate constants via nonlinear least-squares method.
Main Results:
- The three-compartment model effectively analyzed hepatic handling of the radiotracer.
- The hepatic uptake rate constant (k12) showed significant differences among disease groups.
- k12 correlated well with clinical markers like total bilirubin, total bile acids, and indocyanine green (ICG) retention.
Conclusions:
- Three-compartment model analysis of [99mTc]-pyridoxyl-5-methyltryptophan is a valuable tool for evaluating hepatic transport function.
- The k12 parameter is the most sensitive indicator for assessing liver function and disease severity.