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[Heavy particle therapy for prostate cancer].
1Department of Urology, Tokyo Kosei Nenkin Hospital.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|February 18, 2005
Summary
Heavy ion therapy, using carbon ion beams, shows excellent survival and local control for prostate cancer. Adjustments to dosage and treatment fields improved safety, reducing late side effects.
Area of Science:
- Radiation Oncology
- Medical Physics
- Oncology
Background:
- Heavy particle (ion) beams offer high relative biological effectiveness and improved dose distribution.
- Establishing heavy ion therapy for prostate cancer requires robust clinical trial data.
Purpose of the Study:
- To evaluate the efficacy and safety of carbon ion beam therapy for localized and locally advanced prostate cancer.
Main Methods:
- Three clinical trials involving 247 patients with T1b-T3 prostate cancer were conducted.
- Carbon ion beam irradiation was administered over 20 sessions within 5 weeks, with or without endocrine therapy.
- Dosage and radiation field adjustments were made based on observed toxicity.
Main Results:
- Excellent overall and cause-specific survival rates were observed.
- Local control was achieved in all but one patient.
- Grade 3 late morbidity in the rectum and/or bladder/urethra occurred in 7 patients at higher doses, leading to dose reduction to 66 GyE.
Conclusions:
- Carbon ion therapy demonstrates significant potential for treating localized and locally advanced prostate cancer.
- The treatment shows promising efficacy with manageable toxicity after dose and field adjustments.
- Further investigation into optimized treatment protocols for carbon ion therapy in prostate cancer is warranted.