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Updated: Aug 19, 2026

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
Published on: April 27, 2018
[Prostate cancer gene therapy]
1Department of Urology, Okayama University Graduate School of Medicine and Dentistry.
Abstract:
With the advance in genetic engineering, tumor biology and immunology, gene therapy has been recognized as a promising new treatment option for cancer including prostate cancer. Several clinical trials of prostate cancer gene therapy are currently underway, using therapeutic genes which include suicide genes, immunomodulatory genes, tumor suppressor genes and anti-oncogenes. Although the gene therapy for prostate cancer as a clinical alternative is still early stage which requires several technological breakthrough, some information obtained from clinical trial indicates full potential of prostate cancer gene therapy. Concordant progress both in the basic research and gene therapy technology will make prostate cancer gene therapy ready for wide-scale of practice in the future. In this report, general concept and current progress in prostate cancer gene therapy are summarized.
Insights
Gene therapy shows promise for treating prostate cancer, with ongoing clinical trials exploring various therapeutic genes. Further advancements in technology and research are expected to enable widespread clinical practice.
Area of Science:
- Oncology
- Immunology
- Genetic Engineering
Context:
- Prostate cancer treatment landscape evolving with advancements in biological sciences.
- Gene therapy emerging as a potential therapeutic modality for various cancers.
Purpose:
- To summarize the general concepts and current progress of gene therapy for prostate cancer.
- To highlight the potential of gene therapy based on early clinical trial data.
Summary:
- Gene therapy utilizes therapeutic genes (suicide, immunomodulatory, tumor suppressor, anti-oncogenes) to combat prostate cancer.
- Clinical trials are actively investigating the efficacy and safety of these gene-based approaches.
- Despite being in early stages, prostate cancer gene therapy demonstrates significant potential.
Impact:
- Gene therapy offers a promising new avenue for prostate cancer treatment.
- Continued progress in basic research and technology will facilitate future clinical application.
- Potential for gene therapy to become a standard treatment option for prostate cancer.
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