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Related Experiment Videos

Bone lesions in systemic acne (acne fulminans).

B P O'Malley, I Anderson, F D Rosenthal

    The British Journal of Dermatology
    |June 1, 1979
    PubMed
    Summary

    This case report details a rare presentation of bone lesions in a patient with acne fulminans. High-dose steroids effectively managed the severe pain associated with these lytic bone lesions.

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    Area of Science:

    • Rheumatology
    • Dermatology
    • Orthopedics

    Background:

    • Acne fulminans is a rare, severe form of acne vulgaris often associated with systemic symptoms.
    • Autoimmune complex disease is the suspected etiology for acne fulminans.
    • Bone involvement has not been previously reported in autoimmune disorders presenting with acne fulminans.

    Observation:

    • An 18-year-old male presented with severe sternal pain and acne fulminans.
    • Radiographs and technetium bone scans revealed multiple lytic bone lesions in the sternum, iliac crest, and greater trochanter.
    • Bone histology showed only reactive changes.

    Findings:

    • High-dose prednisolone provided significant pain relief.
    • Pain recurred upon dose reduction below 10 mg daily.
    • This presentation suggests a potential link between acne fulminans and lytic bone lesions.

    Implications:

    • This case highlights a previously undocumented manifestation of acne fulminans.
    • Further research is warranted to explore the pathophysiology linking autoimmune processes, acne fulminans, and bone lytic lesions.
    • This finding may necessitate a broader differential diagnosis for patients presenting with severe bone pain and acne fulminans.

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