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Strategies for improving the diagnostic specificity of the frequency doubling perimeter
Govert P Heeg1, Remco Stoutenbeek, Nomdo M Jansonius
1Department of Ophthalmology, University Hospital Groningen, 9700 RB Groningen, The Netherlands.
Purpose:
To evaluate various strategies designed to improve the specificity of the interpretation of results obtained with the frequency doubling technology perimeter (FDT) used in the full-threshold mode.
Methods:
Three different strategies were compared using data from 452 glaucoma patients and 237 healthy subjects: combining several FDT parameters from a single test, combining the FDT test with a GDx test, and confirming an abnormal FDT test result with a repeat test.
Results:
Confirming an abnormal FDT test result with a repeat test yielded a specificity increase of 0.10, from 0.80 to 0.90, at the expense of some loss of sensitivity for early but not for moderate or severe glaucoma. Combining several FDT parameters from a single test and combining FDT with GDx did not yield any noticeable increase in diagnostic performance.
Conclusions:
A modest increase in FDT diagnostic performance can be obtained by the confirmation of an abnormal test result with a repeat test.
