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Updated: Jul 23, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Late mortality after head injury
B Pentland1, L S Hutton, P A Jones
1Astley Ainslie Hospital, Edinburgh EH9 2HL. Brian.Pentland@lpct.scot.nhs.uk
Objectives:
To investigate mortality trends in a cohort of people admitted to a regional head injury unit with all severities of injury in the calendar year 1981.
Methods:
A computerised database with details of 1919 admissions was compared with deaths registered by the NHS Central Register, Scotland for the years 1981 to mid-2002. Death certificate information for matches was analysed.
Results:
The 1919 admissions referred to 1871 individuals, comprising 93 severe, 205 moderate, and 1573 minor injuries according to Glasgow coma scale criteria. There were 57 deaths (42 severe head injuries, eight moderate, seven minor) during the initial admission, and 340 (six severe, 33 moderate, 301 minor) in the subsequent years. Substance abuse, principally alcohol, was a factor in 37 deaths, suicide accounted for 20, and accidents for 25. The great majority of these latter deaths were in people under the age of 70 years.
Conclusion:
Premature deaths after predominantly minor head injury are commonly alcohol related or the result of suicide or accidents.
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