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Biomarkers: potential uses and limitations.

Richard Mayeux¹

¹Gertrude H. Sergievsky Center and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. rpm2@columbia.edu

Neurorx : the Journal of the American Society for Experimental Neurotherapeutics

|February 18, 2005

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Biomarkers, or measurable indicators of disease, are crucial for understanding neurological conditions. This review highlights their use in research and clinical practice, emphasizing valid assessment and analysis.

Area of Science:

Neurology
Biochemistry
Epidemiology

Background:

Biomarkers, defined as alterations in tissues or body fluids, offer insights into neurological disease.
They aid in classifying diseases, identifying risk factors, and understanding disease pathogenesis.
Biomarkers can track disease progression from early stages to terminal phases.

Purpose of the Study:

To review the significant applications of biomarkers in clinical research.
To emphasize the importance of valid biomarker assessment across different disease stages.
To discuss factors influencing biomarker measurement and analysis.

Main Methods:

Literature review of biomarker applications in neurological disease.
Discussion of biomarker validity, variability, and analytical issues.

Related Experiment Videos

Recommendations for addressing bias and confounding in biomarker studies.

Main Results:

Biomarkers are versatile tools in epidemiology, clinical trials, and diagnostics.
Accurate biomarker assessment requires consideration of disease stage and potential variability.
Addressing analytical challenges is key to reliable biomarker utilization.

Conclusions:

Biomarkers are essential for advancing the understanding and management of neurological disorders.
Rigorous validation and careful analysis are necessary for effective biomarker implementation.
This review provides a framework for the optimal use of biomarkers in clinical investigation.