Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cell therapy for stroke.

Sean I Savitz¹, Jonathan H Dinsmore, Lawrence R Wechsler

¹Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. ssavitz@bidmc.harvard.edu

Neurorx : the Journal of the American Society for Experimental Neurotherapeutics

|February 18, 2005

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Locked-in syndrome.

Handbook of clinical neurology·2026

Same author

Methodological considerations in PISCES 3: a randomized, placebo-controlled study of intracerebral stem cells in subjects with disability following an ischemic stroke.

Frontiers in stroke·2026

Same author

Transient ischemic attack in the twenty first century: is it still a useful construct?

Frontiers in stroke·2026

Same author

Competition between a transmembrane helix on Scap and a membrane cholesterol regulates Scap-Insig interaction and SREBP activation.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Association of Ischemic Core Hypodensity With Thrombectomy Treatment Effect in Large Core Stroke: A Secondary Analysis of the SELECT2 Randomized Controlled Trial.

Stroke·2025

Same author

Structural mechanism of CB<sub>1</sub>R binding to peripheral and biased inverse agonists.

Nature communications·2024

Same journal

Pediatric neurotherapy.

NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics·2013

Same journal

Drug development in critical times.

NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics·2006

Same journal

Spinal muscular atrophy: a test case for drug development in orphan diseases.

NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics·2006

Same journal

Community neurorehabilitation: a synthesis of current evidence and future research directions.

NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics·2006

Same journal

Issues in selecting outcome measures to assess functional recovery after stroke.

NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics·2006

Same journal

Behavioral tests for preclinical intervention assessment.

NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics·2006

See all related articles

Cell transplantation shows promise for stroke recovery in animal and human studies. Research is exploring various stem cell sources to improve outcomes for stroke patients.

Area of Science:

Neuroscience
Regenerative Medicine
Clinical Neurology

Background:

Cell transplantation is being investigated for stroke recovery.
Animal models show enhanced recovery after focal cerebral ischemia.
Clinical trials are evaluating neuronal cell lines and fetal neurons for stroke patients.

Purpose of the Study:

To review preclinical and clinical studies on cell therapy for stroke.
To highlight current knowledge gaps in implant source biology.
To discuss stroke-specific factors influencing cell therapy success.

Main Methods:

Review of preclinical studies on various human stem cell sources (brain, bone marrow, umbilical cord, adipose).
Analysis of clinical trials using immortalized neuronal cell lines and porcine fetal neurons.

Related Experiment Videos

Discussion of biological factors and stroke conditions impacting cell transplantation.

Main Results:

Growing evidence supports cell transplantation for stroke recovery in animal models.
Clinical investigations are underway for specific cell types in chronic stroke.
Understanding of implant biology and stroke environment remains limited.

Conclusions:

Cell therapy holds potential for stroke treatment.
Further research is needed on stem cell biology and stroke conditions.
Optimizing cell sources and delivery is crucial for clinical success.