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Updated: Aug 19, 2026
Gramicidin-based Fluorescence Assay; for Determining Small Molecules Potential for Modifying Lipid Bilayer Properties
Published on: October 13, 2010
Synthesis and biological evaluation of gramicidin S dimers
Gijsbert M Grotenbreg1, Martin D Witte, Peter A V van Hoof
1Leiden Institute of Chemistry, Gorlaeus Laboratories, P. O. Box 9502, 2300, RA Leiden, The Netherlands.
Abstract:
The design and synthesis of analogues of the cyclic beta-sheet gramicidin S (GS), having additional functionalities in their turn regions, is reported. The monomeric GS analogues were transformed into dimers and their activities towards biological membranes, through antimicriobial and hemolytic assays, were evaluated. Finally, conductivity measurements have been performed to elucidate ion channel forming properties.
