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New criterial for cytologic diagnosis of adenoid cystic carcinoma
Hitoshi Hara1, Toshio Oyama, Koichi Suda
1Department of Biochemistry, Akebono Medical Welfare Center, and Pathology Division, Yamanashi Prefectural Central Hospital, Yamanashi, Japan. hara2@nns.ne.jp
Objective:
To formulate new criteria for adenoid cystic carcinoma (ADCC).
Study Design:
The usefulness of 17 items for a cytologically definitive diagnosis of ADCC was examined. The frequency (- - +++) of the 17 items in 18 cases of ADCC and 10 non-ADCC cases (pleomorphic adenoma, basal cell adenoma, myoepithelioma and epithelial-myoepithelial carcinoma) that displayed mimicking cytology was examined cytologically. The total score for cases of ADCC was compared with that for non-ADCC cases.
Results:
The 17 items included broad intercellular spaces with adhesion; green, granular/cobwebby cytoplasm with translucent intercellular matrix with Papanicolaou staining; coarse hyperchromatin with little nuclear clearing; indistinct and partially distinct nucleoli; small nuclei; broad, smooth margin (SM) space; and translucent M/HG/SM. All cases with a total score of > 21 were ADCC (93.8%). All cases with a total score of < 12 were non-ADCC (87.5%).
Conclusion:
The 17 items appear to be useful as new criteria for ADCC.
