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Related Experiment Videos

NOD1 variation, immunoglobulin E and asthma.

Pirro Hysi1, Michael Kabesch, Miriam F Moffatt

  • 1Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

Human Molecular Genetics
|February 19, 2005
PubMed
Summary
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Childhood asthma risk may be linked to the NOD1 gene, an intracellular pattern-recognition receptor. A specific NOD1 gene variant (ND(1)+32656*2) is associated with higher IgE levels and increased asthma risk in children.

Area of Science:

  • Immunology
  • Genetics
  • Pulmonology

Background:

  • Asthma is a familial inflammatory airway disease.
  • Childhood microbial exposures may protect against asthma via unknown mechanisms.
  • Pattern-recognition receptors (PRRs) like NOD1 detect microbial components, initiating inflammation.

Purpose of the Study:

  • To investigate the role of the NOD1 gene in childhood asthma.
  • To identify polymorphisms in the NOD1 gene and their association with asthma and IgE levels.

Main Methods:

  • Systematic search for polymorphisms in the NOD1 gene.
  • Analysis of an insertion-deletion polymorphism (ND(1)+32656) in family cohorts.
  • Association study of the polymorphism with asthma in children and controls.

Related Experiment Videos

Main Results:

  • A NOD1 gene polymorphism (ND(1)+32656) explained 7% of IgE variation (P<0.0005).
  • Allele*2 (insertion) associated with high IgE and strongly with asthma (OR 6.3).
  • Differential protein binding observed for ND(1)+32656 alleles in epithelial cells.

Conclusions:

  • The NOD1 gene polymorphism is linked to childhood asthma susceptibility.
  • Intracellular recognition of bacterial products by NOD1 influences asthma development.
  • The deletion allele was also associated with inflammatory bowel disease.