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Updated: Aug 19, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
Relative predicted protein levels of functionally associated proteins are conserved across organisms
Gila Lithwick1, Hanah Margalit
1Department of Molecular Genetics and Biotechnology, The Faculty of Medicine, The Hebrew University Jerusalem 91120, Israel.
Abstract:
We show that the predicted protein levels of functionally related proteins change in a coordinated fashion over many unicellular organisms. For each protein, we created a profile containing a protein abundance measure in each of a set of organisms. We show that for functionally related proteins these profiles tend to be correlated. Using the Codon Adaptation Index as a predictor of protein abundance in 48 unicellular organisms, we demonstrated this phenomenon for two types of functional relations: for proteins that physically interact and for proteins involved in consecutive steps within a metabolic pathway. Our results suggest that the protein abundance levels of functionally related proteins co-evolve.
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