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Icodextrin re-absorption varies with age in children on automated peritoneal dialysis

Allison Dart1, Janusz Feber, Hubert Wong

  • 1Department of Pediatrics, Division of Nephrology, Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada.

Pediatric Nephrology (Berlin, Germany)
|February 19, 2005
PubMed

Insights

Icodextrin fluid removal in pediatric automated peritoneal dialysis (APD) patients showed significant age correlation. Young children may experience Icodextrin re-absorption, impacting treatment efficacy.

Area of Science:

  • Pediatric Nephrology
  • Renal Replacement Therapy

Background:

  • Limited data exists on Icodextrin use in pediatric patients.
  • Previous assumptions suggested age-independent Icodextrin characteristics.

Purpose of the Study:

  • To evaluate Icodextrin ultrafiltration in a cohort of young pediatric automated peritoneal dialysis (APD) patients.
  • To investigate potential age-related differences in Icodextrin behavior.

Main Methods:

  • Calculated net Icodextrin daytime dwell ultrafiltration (ml/h/m2) in pediatric APD patients.
  • Analyzed fluid removal in relation to patient age and peritoneal equilibration test (PET) results.

Main Results:

  • Half of the patients exhibited Icodextrin re-absorption, even with reduced dwell times.
  • Re-absorption was observed in all four patients on cyclic nocturnal APD, three of whom were high transporters.
  • Icodextrin fluid removal significantly correlated with patient age (Spearman rank r=0.8571, P=0.0107).

Conclusions:

  • Icodextrin appears to behave differently in young pediatric patients compared to older individuals.
  • Age is a significant factor influencing Icodextrin efficacy in pediatric APD.
  • Further research is needed to optimize Icodextrin use in this population.

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