Related Experiment Video

Updated: Aug 19, 2026

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
10:39

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module

Published on: June 18, 2015

Potential growth inhibitory effect of maitake D-fraction on canine cancer cells

Sensuke Konno1

  • 1Department of Urology, New York Medical College, Munger Pavilion 4th Floor, Valhalla, NY, 10595, USA.

Veterinary Therapeutics : Research in Applied Veterinary Medicine
|February 19, 2005
PubMed

Insights

Maitake mushroom

Area of Science:

  • Veterinary Oncology
  • Natural Product Chemistry

Background:

  • Maitake mushroom (Grifola frondosa) contains bioactive compounds.
  • Beta-glucans are known for their immunomodulatory properties.
  • D-fraction is a specific beta-glucan extract from maitake.

Purpose of the Study:

  • To evaluate the anticancer effects of D-fraction on canine cancer cells.
  • To compare D-fraction's efficacy with other beta-glucan products.
  • To investigate D-fraction's potential in veterinary cancer treatment.

Main Methods:

  • In vitro evaluation of D-fraction on canine cancer cell lines (CF33, CF21, CL-1).
  • Assessment of D-fraction's impact on human cancer cells.
  • Comparative analysis with other beta-glucan products.

Main Results:

  • D-fraction demonstrated significant anticancer activity against canine cancer cells.
  • D-fraction inhibited cell growth and induced cell death in canine cancer models.
  • Similar potent effects were observed in certain human cancer cell lines.
  • Other beta-glucan products showed no comparable effects on canine cancer cells.

Conclusions:

  • D-fraction is a potent natural agent with significant anticancer properties.
  • D-fraction shows promise for treating canine and other veterinary cancers.
  • Its efficacy distinguishes it from other beta-glucan products in veterinary oncology.

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...