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Association between BDNF val66 met genotype and episodic memory.

Emma Dempster1, Timothea Toulopoulou, Colm McDonald

  • 1Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
|February 19, 2005
PubMed
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The brain-derived neurotrophic factor (BDNF) val66met polymorphism impacts episodic memory. The met66 allele was linked to poorer memory scores in unaffected relatives, supporting prior research.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • The brain-derived neurotrophic factor (BDNF) val66met polymorphism is linked to episodic memory variations.
  • Replication of these findings is crucial for understanding genetic influences on memory.

Purpose of the Study:

  • To investigate the association between the BDNF val66met polymorphism and episodic memory.
  • To replicate previous findings in a family-based study.

Main Methods:

  • Genotyping of 206 individuals (92 with schizophrenia/related disorder, 114 unaffected relatives) for the BDNF val66met polymorphism.
  • Episodic memory assessed using the Wechsler Memory Scale, revised version (WMS-R).
  • Regression analysis correlating WMS delayed logical memory scores with genotype, controlling for age, sex, and IQ.

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Main Results:

  • The met66 allele showed a non-significant trend towards lower WMS delayed scores in the overall sample (R2 = 0.014, P = 0.09).
  • In unaffected relatives analyzed separately, the met66 allele was significantly associated with lower WMS delayed scores (R2 = 0.077, P = 0.01).

Conclusions:

  • The BDNF val66met polymorphism's effect on episodic memory may be more pronounced in unaffected individuals.
  • Findings partially replicate previous research, suggesting a specific role in familial memory function.