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[Lead toxicity in mice embryos].

J R Maisin, M Lambiet-Collier, L de Saint-Georges

    Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

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    Lead acetate administration to female mice before mating and during pregnancy impaired fertility. Embryonic development showed no initial lesions, but lead inclusions were observed in mitochondria by day 7.

    Area of Science:

    • Reproductive toxicology
    • Developmental biology
    • Environmental health

    Context:

    • Lead acetate exposure during critical reproductive periods.
    • Investigation of early embryonic development following maternal lead exposure.
    • Ultrastructural analysis of embryonic tissues.

    Purpose:

    • To assess the impact of lead acetate on female mouse fertility.
    • To examine ultrastructural changes in early-stage embryos exposed to lead.
    • To identify the timing and location of lead accumulation in developing embryos.

    Summary:

    • Maternal administration of 0.1% lead acetate before coitus and during pregnancy significantly impaired fertility in female mice.
    • Ultrastructural examination of embryos revealed no detectable lesions until day 7 post-fertilization.

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  • At day 7, lead inclusions were identified within the mitochondria of embryonic cells, indicating a specific site of accumulation.

    • Impact:

    • Highlights the detrimental effects of lead acetate on reproductive outcomes and early embryonic development.
    • Identifies mitochondrial lead inclusions as a potential indicator of lead toxicity during embryogenesis.
    • Provides insights into the mechanisms of lead-induced reproductive impairment and developmental toxicity.