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Left ventricular diastolic function parameters in hypertensives

Adewole A Adebiyi1, Akinyemi Aje, Okechukwu S Ogah

  • 1Department of Medicine, College of Medicine, University of Ibadan, Nigeria. wadebiyi@comui.edu.ng

Journal of the National Medical Association
|February 22, 2005
PubMed

Insights

Nigerian hypertensives exhibit distinct left ventricular diastolic function compared to controls. Age and hypertension duration significantly impact these diastolic parameters.

Area of Science:

  • Cardiology
  • Hypertension research
  • Diastolic function assessment

Background:

  • Hypertension is linked to abnormalities in left ventricular diastolic function.
  • Limited research exists on left ventricular diastolic function within African populations.
  • This study addresses the knowledge gap in understanding diastolic function in Nigerian hypertensive individuals.

Purpose of the Study:

  • To evaluate left ventricular diastolic function in Nigerian hypertensive patients.
  • To compare diastolic function indices between hypertensive individuals and normal controls.
  • To identify determinants of left ventricular diastolic function in hypertension.

Main Methods:

  • Echocardiography was performed on 98 hypertensive patients and 99 normal controls.
  • M-mode and Doppler measurements of mitral inflow and pulmonary venous flow were obtained.
  • Analysis included left ventricular wall thickness, mass, and various Doppler-derived diastolic parameters.

Main Results:

  • Hypertensives showed significantly increased left ventricular wall thickness and mass.
  • Significant differences in Doppler parameters (e.g., E/A ratio, deceleration time) were observed between groups.
  • Age and duration of hypertension were primary determinants of diastolic function parameters.

Conclusions:

  • Nigerian hypertensives present with significantly altered left ventricular diastolic function indices compared to controls.
  • These findings highlight the impact of hypertension on cardiac structure and function in this population.
  • The study underscores the importance of age and hypertension duration in diastolic dysfunction.
Abstract

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