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Distribution and determinants of serum creatinine in the general population: the Hordaland Health Study

B E Vikse1, S E Vollset, G S Tell

  • 1Renal Research Group, Institute of Medicine, University of Bergen, Norway. bjorn.vikse@med.uib.no

Scandinavian Journal of Clinical and Laboratory Investigation
|February 22, 2005
PubMed

Insights

Serum creatinine levels are linked to cardiovascular disease (CVD) risk factors. These associations are stronger in older adults, with lifestyle factors being more influential in middle-aged individuals.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Serum creatinine is a recognized cardiovascular disease (CVD) risk factor and a measure of glomerular filtration rate.
  • Understanding serum creatinine determinants in the general population is crucial for public health.

Purpose of the Study:

  • To investigate the determinants of serum creatinine in a large, diverse general population sample.
  • To explore age- and sex-specific associations between serum creatinine and various health and lifestyle factors.

Main Methods:

  • The Hordaland Health Study included over 18,000 participants across different age groups (41-49 and 71-74 years) and sexes.
  • Data collection involved questionnaires on lifestyle and medical history, physical examinations, and non-fasting blood samples.
  • Multiple linear and logistic regression analyses were employed to identify determinants of serum creatinine.

Main Results:

  • Male and older participants exhibited higher serum creatinine levels.
  • In older adults, creatinine correlated with triglycerides, CVD, upper-arm circumference, and antihypertensive use, and inversely with smoking.
  • In middle-aged individuals, creatinine was associated with upper-arm circumference, lipids, exercise, and inversely with smoking and alcohol intake.

Conclusions:

  • High serum creatinine is associated with CVD risk factors in the general population.
  • These associations are more pronounced in older individuals.
  • Lifestyle variables play a relatively greater role in determining serum creatinine in middle-aged subjects.
Abstract

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