Related Experiment Video
Updated: Aug 6, 2026
Candida albicans Biofilm Chip (CaBChip) for High-throughput Antifungal Drug Screening
Published on: July 18, 2012
Candida antigen in the treatment of basal cell carcinoma
Kent Aftergut1, Mary Curry, Jack Cohen
1Department of Dermatology, University of Texas Southwestern, Dallas, Texas, USA.
Background:
Basal cell carcinoma (BCC) is the most common skin cancer. Recently, there has been renewed interest in various immunotherapies in the treatment of BCC. The current study is a randomized, open-label, placebo-controlled trial of intralesional Candida antigen in the treatment of nodular BCC.
Objective:
The objective of this study was to evaluate the safety and efficacy of intralesional Candida antigen in the treatment of BCC.
Results:
In the control group, no patients had complete clearing of their tumor. In the Candida group, 10 of 17 (56%) patients had complete clearing of their tumor. The Fisher exact test was used to compare the two treatment groups. This showed the difference in clearance rates to be of borderline significance, with a p value of .105.
Conclusion:
Although immunotherapy with repeated injections of Candida antigen appears to be effective in clearing superficial and nodular BCCs, it is unlikely to alter our current treatment of BCC.
