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Skin cancer and non-Hodgkin's lymphoma: examining the link
Shasa Hu1, Daniel G Federman, Fangchao Ma
1Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine/Veterans Administration Medical Center, Miami, Florida 33125, USA.
Background:
The incidence rates of melanoma and non-Hodgkin's lymphoma (NHL) have increased substantially worldwide over the past several decades. It has been hypothesized that ultraviolet light exposure through sunlight may be a common environmental risk factor shared by both skin cancer and NHL.
Objective:
The purpose of this study was to better understand the association between skin cancer and NHL and to evaluate its implication in clinical practice.
Methods:
We reviewed the current literature on the link between the two malignancies and on the role of ultraviolet light in the development of NHL. Publications were selected using a PUBMED search with the terms "non-Hodgkin's lymphoma" and "skin cancer." Epidemiologic studies in English and published after 1995 were the focus.
Conclusions:
Large population-based studies support an increased risk of subsequent NHL among patients with skin cancers (both melanoma and nonmelanoma skin cancers) and a risk of skin cancer development in patients with NHL, although support for a direct relationship between ultraviolet light and the incidence of NHL is weak and inconsistent. Given their increased risk of developing skin cancers, patients with a history of NHL may benefit from a full-body examination during their visits.
