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Updated: Aug 19, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
Amyloidosis and auto-inflammatory syndromes
Gilles Grateau1, Isabelle Jéru, Saad Rouaghe
1Service de médecine interne, L'Hôtel-Dieu, Assistance publique-hôpitaux de Paris, Paris, France. gilles.grateau@tnn.ap-hop-paris.fr
Abstract:
Amyloidosis remains currently a severe potential complication of many chronic inflammatory disorders. It is not exactly know why some patients develop a progressive amyloidosis, whereas others do not although latent deposits may be present. A permanent acute phase response, ideally evaluated with serial measurement of serum protein SAA, the precursor of the AA protein deposited in tissues, seems to be a prerequisite to the development of inflammatory (AA) amyloidosis. Genetic factors have however been recently emphasized. Among persistent or emerging causes of AA amyloidosis, hereditary periodic fever syndromes also known as auto-inflammatory syndromes are a group of diseases characterised by intermittent bouts of clinical inflammation with focal organ involvement mainly: abdomen, musculoskeletal system and skin. The most frequent is familial Mediterranean fever which affects patients of Mediterranean descent all over the world. Three other types have been recently clinically as well as genetically characterised. A thorough diagnosis is warranted, as clinical and therapeutic management is specific for each of these diseases.
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