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Prolonged clinically asymptomatic evolution after HIV-1 infection is marked by the absence of complement C4 null
F Hentges1, A Hoffmann, F Oliveira de Araujo
1Department of Immuno-Allergology, Centre Hospitalier de Luxembourg.
Clinical and Experimental Immunology
|May 1, 1992
Abstract:
The length of time after which persons infected with HIV-1 progress to AIDS is variable. Certain alleles at the MHC have been shown to influence negatively the clinical outcome of HIV-1-infected persons and to be associated with special clinical manifestations. We investigated the MHC class I, class II and class III antigens in 54 Caucasian HIV-1-infected persons. The MHC profile of individuals with a prolonged period before AIDS is marked by a lower frequency of C4 null alleles.