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Locally recurrent breast cancer after conservation therapy
Tara L Huston1, Rache M Simmons
1Department of Surgery, The Weill Medical College of Cornell University, The New York-Presbyterian Hospital, 425 E. 61st St., 8th Floor, New York, NY 10021, USA.
American Journal of Surgery
|February 22, 2005
Summary
Breast conservation therapy (BCT) is common for early breast cancer. Local-regional recurrence (LRR) risk factors include positive margins and young age, but prognosis after LRR remains favorable compared to post-mastectomy recurrence.
Area of Science:
- Oncology
- Surgical Oncology
- Radiotherapy Oncology
Background:
- Breast conservation therapy (BCT) is a standard treatment for early-stage breast cancer.
- Local-regional recurrence (LRR) after BCT affects 5-22% of patients with stage 0, I, and II disease.
Purpose of the Study:
- To analyze the risk factors, detection, management, and prognosis of local-regional recurrence (LRR) after breast conservation therapy (BCT).
Main Methods:
- A comprehensive literature search was conducted for studies on BCT and recurrence.
- Data from over 50 articles were collected and analyzed.
Main Results:
- Factors increasing LRR risk include positive margins, high-grade ductal carcinoma in situ (DCIS), young age, and no radiation therapy.
- Prognosis depends on histology, tumor size/stage, detection method, and nodal/skin involvement.
- Salvage mastectomy is the standard treatment for LRR.
Conclusions:
- Prognosis for LRR following BCT is more favorable than for chest wall recurrence after mastectomy.